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IP

Ionis Pharmaceuticals, Inc. (IONS)

NASDAQ • Healthcare

$43.91
-$0.36 (-0.8%)
Market closed

Last close at October 22, 2026 at 20:00 UTC

Open$45.02
Day Range$43.5 - $45.15
Avg. Volume (3M)3.2M
Market Cap$7.2B
52 Week Range
$42.08$86.74
Next EarningsIn 12 daysNov 4, 2026

Metrics Over Time

Where the Money Goes

Q2 2026
Revenueeverything earned$267.9M100%
Gross Profitminus cost of goods$265.2M99%

In plain terms: out of every $100 in revenue, Ionis Pharmaceuticals, Inc. currently loses $43.

Fundamentals & Financials

Revenue (TTM)
$873.7M
Net Income (TTM)
-$564.7M
EPS (TTM)
-$3.46
ROA (TTM)
-18.86%
Current Ratio
7.88

TTM is calculated as the sum of the four most recently completed quarters. This is a standard approach when monthly or real-time data is not available.

Earnings

-14.0%Q1 2026-$1.41
+34.1%Q2 2026-$0.56
+36.7%Q3 2026-$0.69
Next

Nov 4

in 12 daysQ4 2026

% — EPS deviation from the forecast (beat / miss); quarters without a forecast show the reported EPS

Latest report — Q3 2026
Beat +36.7%

Ionis Pharmaceuticals topped consensus on both the top and bottom line in the second fiscal quarter of 2026, reported July 29, 2026, with EPS of -$0.69 topping the -$1.09 estimate by $0.40 and revenue of $267.9 million topping the $189.1 million estimate (+41.7%). Even so, revenue fell 40.7% year over year to roughly $268 million from about $452 million a year ago. Profitability remained shaped by a near-99% gross margin on roughly $265 million of gross profit, while operating income was a loss of about $102 million, leaving operating margin at about -38%. Net income was a loss of roughly $115 million versus net income of about $124 million a year ago. For the next period, consensus calls for EPS of -$1.22 on revenue of $181.8 million.

Next report — what to expect

Ionis Pharmaceuticals, Inc. (IONS) reports on November 4, 2026. Wall Street is looking for EPS of -$1.21 on revenue of $182.4 million. For trailing context, revenue declined -40.7% year over year last quarter. Ionis has beaten EPS in 7 of 8 most recent quarters, keeping attention on any variance versus consensus.

View full earnings history

About Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc. is a biotechnology company listed on NASDAQ as IONS that discovers and develops RNA-targeted therapies. It markets medicines in the United States and, in FY2025, recorded $944.0 million in revenue. The company researches treatments for metabolic, infectious, renal, and ophthalmic diseases, as well as various types of cancer.

Name
Ionis Pharmaceuticals, Inc.
CEO
Brett Monia
Website
www.ionis.com
Industry
Healthcare
Year Founded
1989
Employees
1,480

Today's Snapshot

AI-generated

IONS closed 0.8% below yesterday's close, against a firmer sector. Trading was busier than usual, with volume about half as much again as its usual level. Ionis won orphan-drug status from the U.S. drug regulator for a rare epilepsy treatment.

Trading Volume

Above 10d avg 2.9M

4.9M

vs S&P 500 Today

Moderate Outperformance

+0.45%

Updated: October 22, 2026 at 20:13 UTC

IONS Headlines

Novartis heart drug trial miss hits shares

September 7, 2026

3 min read

Novartis pelacarsen trial misses key endpoint

September 5, 2026

3 min read
View All News

Technical Indicators

0 Buy3 Neutral5 Sell
IONS is rated a strong sell driven by a clear bearish structure: the ADX shows a strong trend, the stock sits well below long-term averages while trading roughly at short-term support, and on-balance volume is deeply negative suggesting distribution. Momentum indicators are mixed — RSI and MACD are neutral-to-slightly bearish while a short-term momentum reading is mildly positive — and volatility is moderate. The classic pivot sits just above the current price, offering a nearby reference. Technical takeaway: Strong sell — a confirmed downtrend with negative volume and long-term moving averages above the market.
All signals
  • EMA (5 indicators)$44.09 - $64.60
    Sell
  • RSI (14)42.69
    Neutral
  • Stochastic %K (14, 3, 3)65.01
    Neutral
  • MACD Level (12, 26)-1.60
    Neutral

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