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IP

Ionis Pharmaceuticals, Inc. (IONS)

NASDAQ • Healthcare

$56.02
-$0.68 (-1.2%)
Market closed

Last close at September 9, 2026 at 20:00 UTC

Open$56.26
Day Range$55.71 - $56.96
Avg. Volume (3M)2.6M
Market Cap$9.3B
52 Week Range
$50.01$86.74
Next EarningsIn 55 daysNov 4, 2026

Metrics Over Time

Where the Money Goes

Q2 2026
Revenueeverything earned$267.9M100%
Gross Profitminus cost of goods$265.2M99%

In plain terms: out of every $100 in revenue, Ionis Pharmaceuticals, Inc. currently loses $43.

Fundamentals & Financials

Revenue (TTM)
$873.7M
Net Income (TTM)
-$564.7M
EPS (TTM)
-$3.46
ROA (TTM)
-18.86%
Current Ratio
7.88

TTM is calculated as the sum of the four most recently completed quarters. This is a standard approach when monthly or real-time data is not available.

Earnings

-14.0%Q1 2026-$1.41
+34.1%Q2 2026-$0.56
+36.7%Q3 2026-$0.69
Next

Nov 4

in 55 daysQ4 2026

% — EPS deviation from the forecast (beat / miss); quarters without a forecast show the reported EPS

Latest report — Q3 2026
Beat +36.7%

Ionis Pharmaceuticals topped consensus on both the top and bottom line in the second fiscal quarter of 2026, reported July 29, 2026, with EPS of -$0.69 topping the -$1.09 estimate by $0.40 and revenue of $267.9 million topping the $189.1 million estimate (+41.7%). Even so, revenue fell 40.7% year over year to roughly $268 million from about $452 million a year ago. Profitability remained shaped by a near-99% gross margin on roughly $265 million of gross profit, while operating income was a loss of about $102 million, leaving operating margin at about -38%. Net income was a loss of roughly $115 million versus net income of about $124 million a year ago. For the next period, consensus calls for EPS of -$1.22 on revenue of $181.8 million.

View full earnings history

About Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc. is a biotechnology company listed on NASDAQ as IONS that discovers and develops RNA-targeted therapies. It markets medicines in the United States and, in FY2025, recorded $944.0 million in revenue. The company researches treatments for metabolic, infectious, renal, and ophthalmic diseases, as well as various types of cancer.

Name
Ionis Pharmaceuticals, Inc.
CEO
Brett Monia
Website
www.ionis.com
Industry
Healthcare
Year Founded
1989
Employees
1,480

Today's Snapshot

AI-generated

IONS closed 1.2% below yesterday's close, while its sector was flat. BofA Securities, an investment bank, lowered its expected Ionis share price to $91 but kept a Buy rating.

Trading Volume

Below 10d avg (3.1M)

2.9M

vs S&P 500 Today

Underperforming Market

-0.80%

Updated: September 9, 2026 at 20:10 UTC

IONS Headlines

Novartis heart drug trial miss hits shares

September 7, 2026

3 min read

Novartis pelacarsen trial misses key endpoint

September 5, 2026

3 min read
View All News

Technical Indicators

0 Buy2 Neutral6 Sell
IONS is exhibiting clear bearish characteristics: price sits below its short-, medium- and long-term moving averages while momentum indicators and MACD are negative, and the large negative on-balance-volume points to distribution rather than accumulation. Trend strength is muted with an ADX under 20, and volatility is moderate at roughly a 4% ATR, while the pivot lies very near the current level. Together these factors favor sellers over buyers in the current technical picture. Technical takeaway: strong sell—price below major averages with negative momentum and heavy volume-driven distribution.
All signals
  • EMA (5 indicators)$58.69 - $69.26
    Sell
  • RSI (14)39.70
    Neutral
  • Stochastic %K (14, 3, 3)26.41
    Neutral
  • MACD Level (12, 26)-0.43
    Sell

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