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UB

Upstream Bio, Inc. (UPB)

NASDAQ • Healthcare

$2.98
+$0.18 (+6.8%)
Market closed

Last close at October 28, 2026 at 20:00 UTC

Open$2.78
Day Range$2.69 - $2.99
Avg. Volume (3M)1.2M
Market Cap$163.2M
52 Week Range
$2.68$33.68

Metrics Over Time

Where the Money Goes

Q2 2026
Revenueeverything earned$773K100%
Gross Profitminus cost of goods$773K100%

Fundamentals & Financials

Revenue (TTM)
$3.1M
Net Income (TTM)
-$156.5M
EPS (TTM)
-$2.9
ROA (TTM)
-55.66%
Current Ratio
27.99

TTM is calculated as the sum of the four most recently completed quarters. This is a standard approach when monthly or real-time data is not available.

Earnings

-8.2%Q1 2026-$0.79
0.0%Q2 2026-$0.75
+6.4%Q3 2026-$0.73

% — EPS deviation from the forecast (beat / miss); quarters without a forecast show the reported EPS

Latest report — Q3 2026
Beat +6.4%

Upstream Bio topped consensus EPS expectations in the second fiscal quarter of 2026, reported August 11, 2026, with EPS of -$0.73 topping the -$0.78 estimate by $0.05. Revenue fell 17.5% to roughly $0.8 million (down from $937,000.00 a year ago), and with gross profit matching revenue at about $0.8 million, results continued to reflect its clinical development-stage focus around verekitug rather than commercial sales. Operating results were dominated by expenses, with operating income at about -$42.4 million, while net income came in at roughly -$39.7 million, a +0.7% year-over-year change (up from -$40.0 million a year ago), alongside EPS improving +1.4% from -$0.74 a year ago. For the next period, consensus calls for EPS of -$0.73 on revenue of $522,455.00.

Next report — what to expect

Upstream Bio, Inc. (UPB) is set to report on November 4, 2026. Wall Street expects EPS of -$0.729 on revenue of $522,455.00. For trailing context, revenue declined -17.5% year over year last quarter. UPB has beaten EPS in 3 of its 8 most recent quarters.

View full earnings history

About Upstream Bio, Inc.

Upstream Bio, Inc. is a NASDAQ-listed biotechnology company in the healthcare sector that operates as a clinical development-stage business focused on new treatments for inflammatory disease. In qualitative terms, it is an early-stage biotech centered on severe respiratory conditions, with its pipeline built around the drug candidate verekitug.

Name
Upstream Bio, Inc.
CEO
E. Rand Sutherland
Website
upstreambio.com
Industry
Healthcare
Year Founded
2021
Employees
75

Today's Snapshot

AI-generated

UPB closed 6.8% higher at 2.98, while its sector was flat. Earnings are due from UPB on 4 November.

Trading Volume

Below 10d avg (1.4M)

1.3M

vs S&P 500 Today

Strong Outperformance

+6.54%

Updated: October 28, 2026 at 20:26 UTC

Technical Indicators

2 Buy1 Neutral5 Sell
UPB shows a strong sell classification despite oversold momentum readings, as the broader trend remains decisively negative and volatility is high. RSI and stochastic readings are oversold, suggesting short-term exhaustion, however the ADX is very high indicating a strong directional move and long-term moving averages sit far above the current price, highlighting a persistent downtrend. ATR indicates elevated intraday swings and OBV remains deeply negative even with a pivot just below the market, implying distribution. Technical takeaway: Strong Sell — oversold signals are present but the dominant downtrend and weak volume prevail.
All signals
  • EMA (5 indicators)$3.06 - $11.05
    Sell
  • RSI (14)28.29
    Buy
  • Stochastic %K (14, 3, 3)7.38
    Buy
  • MACD Level (12, 26)-0.70
    Neutral

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