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ST

Sionna Therapeutics, Inc. (SION)

NASDAQ • Healthcare

$5.96
-$1.21 (-17.0%)
Market closed

Last close at September 18, 2026 at 20:00 UTC

Open$7.12
Day Range$5.9 - $7.19
Avg. Volume (3M)1.4M
Market Cap$269M
52 Week Range
$4.01$54.97
Next EarningsIn 44 daysNov 4, 2026

Metrics Over Time

Fundamentals & Financials

Revenue (TTM)
$0
Net Income (TTM)
-$97.3M
EPS (TTM)
-$2.18
ROA (TTM)
-34.38%
Current Ratio
20.05

TTM is calculated as the sum of the four most recently completed quarters. This is a standard approach when monthly or real-time data is not available.

Earnings

+14.7%Q1 2026-$0.46
-15.4%Q2 2026-$0.6
-1.5%Q3 2026-$0.66
Next

Nov 4

in 44 daysQ4 2026

% — EPS deviation from the forecast (beat / miss); quarters without a forecast show the reported EPS

Latest report — Q3 2026
Miss -1.5%

Sionna Therapeutics’ bottom line came in slightly below expectations as EPS of -$0.66 trailed the -$0.65 estimate (difference -$0.01) in the second fiscal quarter of 2026, based on preliminary results reported August 6, 2026. The early-stage cystic fibrosis-focused biotech posted a GAAP net loss of about $29.9 million, down 65.4% from about $18.1 million a year ago, alongside GAAP operating income of roughly -$32.5 million as it continued funding its pipeline work. EPS of -$0.66 was down 61.0% from -$0.41 in the year-ago quarter. Cash use remained elevated, with negative operating cash flow of about $44.1 million during the period. For the next period, consensus calls for EPS of -$0.63.

View full earnings history

About Sionna Therapeutics, Inc.

Sionna Therapeutics, Inc. is a NASDAQ-listed Biotechnology company in the healthcare sector that researches and develops medicines for cystic fibrosis. The company is an early-stage drug developer rather than a commercial business, with its work centered on advancing a pipeline of cystic fibrosis candidates from Phase 1 through Phase 2 and Phase 2a proof-of-concept studies.

Name
Sionna Therapeutics, Inc.
CEO
Michael Cloonan
Website
www.sionnatx.com
Industry
Healthcare
Year Founded
2019
Employees
59

Today's Snapshot

AI-generated

The day ended with SION 17% lower at 5.96, while its sector was flat. Volume was roughly twice its usual level. Sionna Therapeutics approved a 46% workforce cut to focus spending on two cystic fibrosis drug candidates.

Trading Volume

Above 10d avg 1.6M

3.6M

vs S&P 500 Today

Strong Underperformance

-17.07%

Updated: September 18, 2026 at 20:14 UTC

Technical Indicators

1 Buy2 Neutral5 Sell
SION presents a strong sell profile driven by a well-defined downtrend and elevated volatility. ADX at about 41.86 confirms trend strength to the downside, and multiple moving averages sit far above the market with the 200-day around 35.59, underscoring prolonged weakness. Momentum measures are mixed—oversold RSI contrasts with a negative short-term momentum reading—but heavy volatility (ATR ~1.46) and a pivot level above the current price add downward pressure. Positive OBV is a lone divergence that has not halted the decline. Technical takeaway: Strong sell as dominant downtrend and high volatility outweigh isolated oversold signals.
All signals
  • EMA (5 indicators)$7.10 - $31.49
    Sell
  • RSI (14)29.18
    Buy
  • Stochastic %K (14, 3, 3)35.01
    Neutral
  • MACD Level (12, 26)-3.71
    Neutral

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